| Speedstone | Enchanting | 300 | — | not recorded |
| Spellpower Goggles Xtreme | Engineering | 225 | Spellpower Goggles Xtreme | Schematic: Spellpower Goggles Xtreme |
| Spellpower Goggles Xtreme Plus | Engineering | 270 | Spellpower Goggles Xtreme Plus | Schematic: Spellpower Goggles Xtreme Plus |
| Spiced Chili Crab | Cooking | 225 | Spiced Chili Crab | Recipe: Spiced Chili Crab |
| Spiced Wolf Meat | Cooking | 30 | Spiced Wolf Meat | 14 trainers |
| Spider Belt | Tailoring | 180 | Spider Belt | Pattern: Spider Belt |
| Spider Sausage | Cooking | 200 | Spider Sausage | 14 trainers |
| Spidersilk Boots | Tailoring | 125 | Spidersilk Boots | 13 trainers |
| Spider Silk Slippers | Tailoring | 140 | Spider Silk Slippers | Pattern: Spider Silk Slippers |
| Spitfire Bracers | Leatherworking | 300 | Spitfire Bracers | Pattern: Spitfire Bracers |
| Spitfire Breastplate | Leatherworking | 300 | Spitfire Breastplate | Pattern: Spitfire Breastplate |
| Spitfire Breastplate | Leatherworking | 300 | — | not recorded |
| Spitfire Gauntlets | Leatherworking | 300 | Spitfire Gauntlets | Pattern: Spitfire Gauntlets |
| Spitfire Gauntlets | Leatherworking | 300 | — | not recorded |
| Spotted Yellowtail | Cooking | 225 | Spotted Yellowtail | Recipe: Spotted Yellowtail |
| Standard Scope | — | ? | Smooth Leather Shoulderpads | Standard Scope |
| Standard Scope | Engineering | 110 | Standard Scope | 8 trainers |
| Star Belt | Tailoring | 200 | Star Belt | Pattern: Star Belt |
| Steam Tonk Controller | Engineering | 275 | Steam Tonk Controller | Schematic: Steam Tonk Controller |
| Steel Breastplate | Blacksmithing | 200 | Steel Breastplate | 3 trainers |
| Steel Plate Helm | Blacksmithing | 215 | Steel Plate Helm | 3 trainers |
| Steel Weapon Chain | Blacksmithing | 190 | Steel Weapon Chain | Plans: Steel Weapon Chain |
| Stonescale Oil | Alchemy | 250 | Stonescale Oil | 2 trainers |
| Stormcloth Boots | Tailoring | 250 | Stormcloth Boots | Pattern: Stormcloth Boots |
| Stormcloth Gloves | Tailoring | 220 | Stormcloth Gloves | Pattern: Stormcloth Gloves |
| Stormcloth Headband | Tailoring | 240 | Stormcloth Headband | Pattern: Stormcloth Headband |
| Stormcloth Pants | Tailoring | 220 | Stormcloth Pants | Pattern: Stormcloth Pants |
| Stormcloth Shoulders | Tailoring | 245 | Stormcloth Shoulders | Pattern: Stormcloth Shoulders |
| Stormcloth Vest | Tailoring | 225 | Stormcloth Vest | Pattern: Stormcloth Vest |
| Storm Gauntlets | Blacksmithing | 295 | Storm Gauntlets | Pattern: Storm Gauntlets |
| Stormshroud Armor | Leatherworking | 285 | Stormshroud Armor | Pattern: Stormshroud Armor |
| Stormshroud Gloves | Leatherworking | 300 | Stormshroud Gloves | Pattern: Stormshroud Gloves |
| Stormshroud Pants | Leatherworking | 275 | Stormshroud Pants | Pattern: Stormshroud Pants |
| Stormshroud Shoulders | Leatherworking | 295 | Stormshroud Shoulders | Pattern: Stormshroud Shoulders |
| Stormwind Gift of Friendship | — | ? | Stormwind Gift Collection | Sack of Homemade Bread, Bundle of Cards, Stormwind Pledge Collection |
| Strider Stew | Cooking | 50 | Strider Stew | Recipe: Strider Stew |
| String Together Heads | — | ? | Gurubashi Head Collection | Sacred Cord |
| Strong Anti-Venom | First aid | 130 | Strong Anti-Venom | Manual: Strong Anti-Venom |
| Stronger Hold Gauntlets | Blacksmithing | 300 | — | not recorded |
| Stronghold Gauntlets | Blacksmithing | 300 | Stronghold Gauntlets | Plans: Stronghold Gauntlets |
| Strong Troll's Blood Potion | Alchemy | 125 | Lesser Troll's Blood Elixir | 24 trainers |
| Stylish Blue Shirt | Tailoring | 120 | Stylish Blue Shirt | Pattern: Stylish Blue Shirt |
| Stylish Green Shirt | Tailoring | 120 | Stylish Green Shirt | Pattern: Stylish Green Shirt |
| Stylish Red Shirt | Tailoring | 110 | Stylish Red Shirt | 13 trainers |
| Succulent Pork Ribs | Cooking | 110 | Succulent Pork Ribs | Recipe: Succulent Pork Ribs |
| Sulfuron Hammer | Blacksmithing | 300 | — | Plans: Sulfuron Hammer |
| Sulfuron Hammer | Blacksmithing | 300 | — | not recorded |
| Summon Smithing Hammer | Blacksmithing | 210 | Hammer of Expertise | Signet of Expertise |
| Superior Healing Potion | Alchemy | 215 | Superior Healing Potion | 2 trainers |
| Superior Mana Potion | Alchemy | 260 | Superior Mana Potion | Recipe: Superior Mana Potion |